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KMID : 0381920080380040353
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Korean Journal of Microscopy
2008 Volume.38 No. 4 p.353 ~ p.361
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The Effects of Lycii fructus and Lycii folium on the Liver in Ovariectomized Rat
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Yoon Jung-Sik
Cha Young-Ju
Kim Jeong-Sang
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Abstract
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We aimed to investigate whether the extracts of Lycii fructus, Lycii folium, and estradiol can attenuate on the level of cholesterol on serum and ultrastructure alteration of hepatocytes isolated from ovariectomized rats. Experimental groups are divided into five: Sham (sham-operated), OVX (ovariectomized animal), LCF (OVX, Lycii fructus), LCL (OVX, Lycii folium), and E2 (OVX, estradiol). The body weights of OVX group showed increase compared with Sham, LCF, and LCL groups. The levels of total cholesterol and low-density lipoprotein (LDL) cholesterol were significantly decreased in the LCF and LCL groups compared with those of OVX group. Moreover, the High-density lipoprotein (HDL) cholesterol level was increased in the LCL group. As the results of electron microscopical observation, lipid droplets in the OVX group showed increase compared with Sham group. But in the LCF group not showed lipid droplets. In conclusion, administration of Lycii fructus or Lycii folium lowers the serum cholesterol content of the ovariectomized rats and also the damage of the hepatocytes and formation of lipid droplets.
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KEYWORD
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Lycii fructus, Lycii folium, Ovariectomized rat, Cholesterol, Liver
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